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Hyaluronidase breaks down and helps the body reabsorb hyaluronic acid filler that was injected into the body

Hyaluronidase works by increasing the permeability of tissues, breaking the molecular bonds within the hyaluronic acid, and promoting cellular processes to diffuse the product.

Dermal fillers are made of hyaluronic acid

What Is Hyaluronidase?

Hyaluronic acid is a naturally existing substance found in the body that is injected to hydrate the skin and restore volume. It can last from a few months up to a year. The different hyaluronic acid fillers include Juvéderm, Teosyal, and Restylane. However, hyaluronidase is a substance that can be injected to reverse such treatments if the patient is not happy with the results or if the patient has had a reaction to the filler.

Did You Know?

Hyaluronidase’s unique ability to dissolve chemical agents makes it an effective and ideal additive for local anesthetics. This is because hyaluronidase allows an injected solution to spread throughout the region, penetrate tissue, and even speed up onset.

How Does It Work?

Hyaluronidase treatment is typically suggested to patients who have previously had injections of hyaluronic acid and are looking to change or reverse the results. When an enzyme solution of hyaluronidase is injected underneath the skin of an area that has had previous hyaluronic acid fillers, it can catalyze the body’s ability to break down and reabsorb the filler product. This aims to break down the hyaluronic acid collections from previous injections. Overall, the hyaluronidase does the exact opposite of the filler, as if the filler were never there.

The effectiveness of hyaluronidase

Benefits Of Dermal Fillers

This is one of the benefits of dermal fillers, as the procedures can be easily reversed with this dissolving process. This allows cosmetic surgeons to have the ability to quickly correct injections and ensure patients safety. Before the use of hyaluronidase as a reversal treatment, any errors with hyaluronic acid injections required that patients had to wait for the body to naturally reabsorb the filler over a period of several months. Many studies have been done about the effectiveness of hyaluronidase as a catalyst in the body’s reabsorption and dissolving of hyaluronic acid, concluding that “the use of hyaluronidase reduced patient discomfort within 24 to 48 hours, deterring any patient anxiety or patient dissatisfaction.”

In a study published by the Journal Watch Dermatology in 2005, evidence of hyaluronidase’s ability to break down hyaluronic acid in dermal filler patients was recorded. The study saw a group of 12 volunteers who were injected with 0.2 mL of hyaluronic acid dermal filler in two separate areas of the arm, about 10 cm apart. A few days after they were injected, the test subjects were brought back to be injected with hyaluronidase and saline solution. Hyaluronidase was injected on one dermal filler site, while saline solution was injected on the other. Four to seven days after the hyaluronidase solution injection, 80% of the hyaluronic acid gel had disappeared, while 90% of the hyaluronic acid gel injected with the saline solution had remained.

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